Our group investigates molecular and cellular correlates that underlie adaptive changes in the brain. We use genetic, electrophysiological, anatomical, biochemical and behavioral assays in Drosophila to study signaling networks operating in neurons during long-term plasticity. In addition to local translation mechanisms, global activation of signaling regulated nuclear transcription, a poorly understood process, drives mandatory protein synthesis during persistent changes in neuronal structure and function. Major areas of emphasis in the laboratory include understanding signaling cross-talk during plasticity and the functional analysis of targets of activity regulated transcription factors. Ultimately, we seek to derive conserved conceptual frameworks for signaling networks fundamentally implemented during learning, as well as during maladaptive changes such as addiction and disease.