Publications

DOUGHERTY, K.J., SAWCHUK, M.A. AND S. HOCHMAN. Phenotypic Diversity and Expression of GABAergic Inhibitory Interneurons During Postnatal Development in Lumbar Spinal Cord of GAD67-GFP Mice. Neuroscience. (2009). [pdf]

HAYES, H.B., Y.-H. CHANG, and S. HOCHMAN. An in vitro spinal cord-hindlimb preparation for studying behaviorally relevant rat locomotor function. J Neurophysiol, 101:1114-22 (2009). [pdf]

ZHU, H., CLEMENS, S., SAWCHUK, M. & HOCHMAN, S. Unaltered  D1, D2, D4, and D5 Dopamine receptor mRNA expression and distribution in the spinal cord of the D3-receptor knockout mouse. Journal of Comparative Physiology – A. 194:957–962 (2008). [pdf]

HOCHMAN, S. Depression of spinal sensory transmission during REM sleep: Dopaminergic involvement and insights into Restless Legs Syndrome. J. Neurophysiol 100:549-50 (2008). [pdf]

DOUGHERTY, K.J., & HOCHMAN, S. Spinal Cord Injury Causes Plasticity in a Subpopulation of Lamina I GABAergic Interneurons. J Neurophysiol. 100:212-23 (2008). [pdf]

ANITHA, M., JOSEPH, I., DING, X., TORRE, E.R., SAWCHUK, M.A., MWANGI, S., HOCHMAN, S., SITARAMAN, S.V., ANANIA, F., SRINIVASAN, S., Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function, Gastroenterology, doi: 10.1053/j.gastro.2008.02.018 (2008).

MEACHAM, K.W., GIULY, R.J., GUO, L., HOCHMAN, S., & DEWEERTH, S.P. A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord. Biomedical Microdevices,10:259-69 (2008). [pdf]

HOCHMAN, S. Primer: Spinal Cord. Current Biology. 17:22 R950-955. (2007) [pdf]

ZHU,H., CLEMENS, S., SAWCHUK, M.A., & HOCHMAN, S. Expression and distribution of all dopamine receptor subtypes (D1-D5) in the mouse lumbar spinal cord: A real-time PCR and non-autoradiographic in situ hybridization study. Neuroscience, 149(4): 885-897 (2007). [pdf]

MACHACEK, D.W. & HOCHMAN, S. Noradrenaline unmasks novel self-reinforcing motor circuits within the mammalian spinal cord. J. Neurosci. 26:5920-5928 (2006). [pdf]

CLEMENS, S., RYE, D. & HOCHMAN, S. Restless Legs Syndrome: Revisiting the dopamine hypothesis from the spinal cord angle. Neurology, 67:125-130 (2006). [pdf]

CUI, D., DOUGHERTY, K.J., MACHACEK, D.W., SAWCHUCK, M., HOCHMAN, S. & BARO, D.J. Divergence between motoneuron cell types: Gene expression profiling provides a molecular characterization of functionally discrete somatic and autonomic motoneurons. Physiological genomics, 24:276-89 (2006). [pdf]

SHAY, B.L., SAWCHUK, M.A., MACHACEK, D.W. & HOCHMAN, S. Serotonin produces long-lasting bi-directional changes in spinal reflex strength by activity-independent mechanisms. J. Neurophysiol. 94:2867-77 (2005). [pdf]

DOUGHERTY, K.J., SAWCHUK, M., AND HOCHMAN, S. Properties of mouse spinal lamina I GABAergic interneurons. J. Neurophysiol. 94:3221-7 (2005). [pdf]

CLEMENS, S., SAWCHUK, M., AND HOCHMAN, S. Reversal of the circadian expression of tyrosine-hydroxylase but not nitric oxide synthase levels in the spinal cord of D3 receptor knockout mice. Neuroscience 133(2):353-7 (2005). [pdf]

CLEMENS, S. AND HOCHMAN, S. Conversion of dopamine’s modulatory actions on spinal reflexes from depression to facilitation in D3 receptor knockout mice. Journal of Neuroscience 24:11337-45 (2004). [pdf]

SONG, L., NATH, A., MOORE, A., GEIGER, J.D., AND HOCHMAN, S. HIV-1 Tat protein directly activates neuronal NMDA receptors at an allosteric zinc-sensitive site, Journal of Neurovirology, 9:399-403 (2003). [pdf]

MACDONALD, S.C., FLEETWOOD, I.G., HOCHMAN, S., BROWNSTONE, R., DODD, J.G., CHENG, K.W., AND JORDAN, L.M. Functional motor neurons differentiating from mouse multipotent spinal cord precursors in culture and after transplantation into transected sciatic nerve, Journal of Neurosurgery, 98:1094-1103 (2003). [pdf]

COWLEY, K.C., CINA, C, SCHMIDT, B.J., AND HOCHMAN, S. The isolated rat spinal cord as an in vitro model to study the pharmacological control of spinal myoclonic-like activity, Advances of Neurology, Fahn and Frucht Eds. Lippincott Williams & Wilkins, 89:275-87, 2002. [pdf]

SHAY, B.L. AND HOCHMAN, S. Serotonin alters multisegmental convergence patterns in spinal cord deep dorsal horn and intermediate laminae neurons, Pain, 95:7-14. (2002). [pdf]

MACDONALD, S.C. SIMCOFF, R., JORDAN, L.M. CHENG, K.W. DODD, J.G. & HOCHMAN, S. A Population of oligodendrocytes derivedfrom multipotent neural precursor cells expresses a cholinergic phenotype in culture and responds to ciliary neurotrophic factor, Journal of Neuroscience Research, 68:255-264 (2002). [pdf]

HOCHMAN S., GARRAWAY, S.M.. MACHACEK, D.W. AND SHAY, B.L. 5-HT receptors and the neuromodulatory control of spinal cord function, Motor Neurobiology of the Spinal Cord. CRC Press, Boca Raton T.C. Cope. (ed)., p47-87, 2001. [pdf]

MACHACEK, D.W., GARRAWAY, S.M., SHAY, B.L. & S. HOCHMAN. Serotonin 5-HT2 receptor activation induces a long -lasting amplification of spinal reflex actions in the rat, Journal of Physiology, 537:201-207 (2001). [pdf]

GARRAWAY, S.M. & HOCHMAN, S. Modulatory actions of serotonin, noradrenaline, dopamine and acetylcholine in deep dorsal horn neurons, Journal of Neurophysiology, 86:2183-2194 (2001). [pdf]

NAMAKA, M.P., SAWCHUK, M., MACDONALD, S.C., JORDAN, L.M. & HOCHMAN, S. Precursor proliferation and neurogenesis in postnatal mouse dorsal root ganglia, Experimental Neurology, 172:60-69 (2001). [pdf]

GARRAWAY S.M., AND HOCHMAN, S. Serotonin increases the incidence of primary afferent-evoked long -term depression in rat deep dorsal horn neurons, Journal of Neurophysiology, 85: 1864-1872 (2001). [pdf]

GARRAWAY S.M., AND HOCHMAN, S. Pharmacological characterization of serotonin receptor subtypes modulating primary afferent input to deep dorsal horn neurons in the neonatal rat, British Journal of Pharmacology, 132:1789-1798 (2001). [pdf]

CINA, C., AND HOCHMAN, S. Diffuse distribution of sulforhodamine-labeled neurons during 5-ht evoked locomotion in the neonatal rat thoracolumbar spinal cord, The Journal of Comparative Neurology, 422:590-602 (2000). [pdf]

SCHMIDT, B.J., HOCHMAN, S., AND MACLEAN, J.N. NMDA receptor-mediated oscillatory properties: Potential role in rhythm generation in the mammalian spinal cord, New York Academy of Sciences, In “Neuronal Mechanisms for Generating Locomotor Activity”,860: 189-202, 1998. [pdf]

PARSLEY, C.P., CHENG, K.W., SONG, L. AND HOCHMAN, S. Thin slice CNS explants maintained on collagen-coated culture dishes, Journal of Neuroscience Methods, 80:65-74 (1998). [pdf]

HOCHMAN, S. AND SCHMIDT, B.J. Whole-cell recording of locomotor-like activity from motoneurons in the neonatal rat spinal cord in vitro, Journal of Neurophysiology, 79:743-752 (1998). [pdf]

HOCHMAN, S., GARRAWAY, S.M. AND POCKETT, S. Membrane properties of deep dorsal horn neurons from neonatal rat spinal cord in vitro, Brain Research, 767:214-219 (1997). [pdf]

GARRAWAY, S., POCKETT, S. AND HOCHMAN, S. Primary afferent-evoked synaptic plasticity in deep dorsal horn neurons from neonatal rat spinal cord in vitro, Neuroscience Letters, 230:61-64 (1997). [pdf]

MACDONALD, S.C. AND HOCHMAN, S.  A variation of the tissue print technique for studying isolated spinal cord cells in situ.  Neurosci. Lett. 223:85-88 (1997).

MACLEAN, J.N., HOCHMAN, S., AND MAGNUSON, D.S.K. Lamina VII neurons are rhythmically active during locomotor-like activity in the neonatal rat spinal cord. Neurosci. Lett. 197:9-12 (1995).

HOCHMAN, S., JORDAN, L.M., AND SCHMIDT, B.J.  TTX-resistant NMDA receptor-mediated voltage oscillations in mammalian lumbar motoneurons.  J. Neurophysiol. 72:2559-2562 (1994).

HOCHMAN, S., JORDAN, L.M., AND MACDONALD, J.F. N-methyl-D-aspartate receptor-mediated voltage oscillations in neurons surrounding the central canal in slices of rat spinal cord. J. Neurophysiol. 72:565-577 (1994).

HOCHMAN, S. AND MCCREA, D.A.  Effects of chronic spinalization on reflexes in ankle extensors. I. Composite Ia EPSPs in four motoneuron pools. J. Neurophysiol. 71:1452-1467 (1994).

HOCHMAN, S. AND MCCREA, D.A. Effects of chronic spinalization on reflexes in ankle extensors. II. Motoneuron electrical properties. J. Neurophysiol. 71:1468-1479 (1994).

HOCHMAN, S., AND MCCREA, D.A. Effects of chronic spinalization on reflexes in ankle extensors. III. Composite Ia EPSPs in motoneurons separated into presumed motor-unit types. J. Neurophysiol. 1480-1490 (1994).

FEDIRCHUK, B., HOCHMAN, S., AND SHEFCHYK, S.J. An intracellular study of perineal and hindlimb afferent inputs onto sphincter motoneurons in the decerebrate cat. Exp. Brain Res. 89:511-516 (1992).

HOCHMAN,S., FEDIRCHUK, B., AND SHEFCHYK, S.J. Membrane electrical properties of external urethral sphincter and external anal sphincter motoneurons in the decerebrate cat. Neurosci. Lett. 127:87-90 (1991).

Leica applications brief

SONG, L., SAWCHUK, M & HOCHMAN S. Ultrathin CNS slices: Enhanced visualization of neuron structure for electrophysiology and imaging, (1997). [pdf]

Recent Abstracts

SHRECKENGOST, J., QUEVEDO, J.  & HOCHMAN, S. Primary afferent depolarization of low-threshold afferents does not require trisynaptic pathways. (2009) Soc. Neurosci. Abst. 35. [pdf]

ZIMMERMAN, A. & HOCHMAN, S. Electrophysiological identification of intermediolateral sympathetic preganglionic neuron subpopulations in the neonatal mouse. (2009) Soc. Neurosci. Abst. 35. [pdf]

TODD, J.L., DEWEERTH, S.P. & HOCHMAN, S. Sacral dorsal column stimulation induced locomotor-like activity is enhanced via tubocurarine and output-based positive feedback. (2009) Soc. Neurosci. Abst. 35. [pdf]

HAYES, H.B., CHANG, Y-H., & HOCHMAN, S. Afferent signaling and interneuronal activity during non-fictive locomotion in the in vitro spinal cord - hindlimb rat preparation. (2009) Soc. Neurosci. Abst. 35. [pdf]

GOZAL, E.A., HAYES, H.B. & HOCHMAN, S.  Effects of the Trace Amines on Hindlimb Motor Output in the Neonatal Rat Spinal Cord. (2008) Soc. Neurosci. Abst. 34. [pdf]

SHRECKENGOST, J., QUEVEDO,J.N., CALVO, J., & HOCHMAN, S. A ‘direct’ form of inhibitory control of spinal sensory input. (2008) Chrsistopher and Dana Reeve spinal cord symposium. [pdf]

CALVO, J.R., HOCHMAN, S. & QUEVEDO, J.N. Modulation of sensory-evoked field potentials by monoamines in the hemisect spinal cord of the mouse. (2008) Soc. Neurosci. Abst. 34. [pdf]

TODD, J.L., DEWEERTH, S.P., & HOCHMAN, S. Capsaicin-sensitive afferents in the sacral dorsal column activate the hindlimb locomotor CPG. (2008) Soc. Neurosci. Abst. 34. [pdf]

HAYES, H.B., HOCHMAN, S., & CHANG, Y-H. Kinematics of a Walking Spinal Cord: Insights from a Novel Isolated Spinal Cord-Hindlimb Preparation. North American Congress on Biomechanics (2008).[pdf]

HAYES, H.B., CHANG, Y-H, & HOCHMAN, S. Mechanosensory Effects on Hindlimb Locomotor Function in an In Vitro Spinal Cord-Hindlimb Rat Preparation. (2008) Soc. Neurosci. Abst. 34. [pdf]

TODD,J.L., DEWEERTH,S.P. & HOCHMAN,S. Sacral spinal dorsal column stimulation activates locomotor-like activity via a cholinergic pathway in the neonatal rat spinal cord. (2007) Soc. Neurosci. Abst. 33. [pdf]

GOZAL, E.A., SAWCHUK, M.A. & HOCHMAN, S. Trace amine immunolabeling and motor patterning in the neonatal rat spinal cord. (2007) Soc. Neurosci. Abst. 33. [pdf]

MEACHAM, K.W., GUO, L., HOCHMAN, S. & DEWEERTH, S.P. Elastomer-based multi-electrode arrays for activation of spinal cord white matter tracts: evaluation of surface stimulation selectivity. (2007) Soc. Neurosci. Abst. 33.1. [pdf]

CLEMENS, S., ZHU, H., SUBRAMANIAM, S., SAWCHUK, M.A., & S. HOCHMAN. D3 receptor knockout mice have altered circadian gene expression patterns in spinal sympathetic preganglionic neurons. (2006) Soc. Neurosci. Abst. 32. [pdf]

GOZAL, EA, WILLIAMS, KK, SAWCHUK, MA & S. HOCHMAN. Trace amines recruit motor activity in the isolated neonatal rat spinal cord. (2006) Soc. Neurosci. Abst. 32. [pdf]

DOUGHERTY, KJ & S. HOCHMAN. Selective plasticity in subpopulations of mouse lamina I GABAergic neurons after chronic spinal injury. (2006) Soc. Neurosci. Abst. 32. [pdf]

M. HERNÁNDEZ-RODRÍGUEZ; J. R. CALVO; S. HOCHMAN; J.N. QUEVEDO. Monoaminergic modulation of pathways mediating sensory-evoked pad in the hemisected spinal cord of the mouse. (2006) Soc. Neurosci. Abst. 32. [pdf]

BRANT, H.E., HOCHMAN, S., & CHANG, Y.H. A comparison of motor outcomes between in vitro and in vivo rat locomotion. (2006) Soc. Neurosci. Abst. 32 [pdf]

CUI D, SUBRAMANIAM S, DOUGHERTY KJ, MACHACEK DW, SAWCHUK MA, BARO DJ & HOCHMAN S. Limited changes in lumbar motoneuron gene expression 3 weeks after thoracic spinal cord transection. Soc. Neurosci. Abst. 31. (2005). [pdf]

BREEN B, DOUGHERTY KJ, WILHELM J & HOCHMAN S. Comparison of two forms of epileptiform activity in spinal cord. Soc. Neurosci. Abst. 31. (2005). [pdf]

MACHACEK DW, SAWCHUCK M & HOCHMAN S. Monoaminergic modulation of Recurrent Inhibition in the Neonatal Rat. Soc. Neurosci. Abst. 31. (2005). [pdf]

CLEMENS S, ZHU H, SUBRAMANIAM S, SAWCHUK M & HOCHMAN S. Expression profiling reveals circadian patterns of gene expression in the spinal sympathetic system: Focus on monoaminergic mechanisms. Soc. Neurosci. Abst. 31. (2005). [pdf]

DOUGHERTY KJ & HOCHMAN S. Lamina I GABAergic Interneurons Become More Excitable Following Spinal Cord. Soc. Neurosci. Abst. 31. (2005). [pdf]

DOUGHERTY KJ, SAWCHUK, M & HOCHMAN S. Continuing characterization of GABAergic neurons in spinal cord lamina I of GAD67-EGFP expressing transgenic mice, Soc. Neurosci. Abst. 30. (2004). [pdf]

CLEMENS, S & HOCHMAN, S. Monosynaptic and longer-latency reflexes in the mouse spinal cord differ in their responses to dopamine and D2-like agonists and antagonists, Soc. Neurosci. Abst. 30. (2004). [pdf]

SAWCHUK, M, CLEMENS, S & HOCHMAN, S. Circadian variation in tyrosine-hydroxylase levels in sympathetic intermediolateral nucleus of spinal cord & greatly reduced staining in D3 receptor knockout mice, Soc. Neurosci. Abst. 30. (2004). [pdf]

GIESEKER, E, WILLIAMS, K, SAWCHUK, M & HOCHMAN, S. The trace amine tyramine is found in spinal ventral horn neurons and induces locomotor-like activity in the isolated neonatal rat spinal cord, Soc. Neurosci. Abst. 30. (2004). [pdf]

HOCHMAN, S, WILHELM, JC, DOUGHERTY, KJ, MACHACEK D & ADUONUM, A. Dependence on metabotropic glutamate receptor activation but not Ca2+ entry in the genesis of novel convulsant-induced bursting in rat spinal cord, Soc. Neurosci. Abst. 30. (2004). [pdf]

ZHU, H, SAWCHUK, M, CLEMENS, S & HOCHMAN, S. Distribution of D1-D5 dopamine receptor mrna in mouse spinal cord, Soc. Neurosci. Abst. 30. (2004). [pdf]

GUERTIN, PA, ROUILLARD, C, LÉVESQUE, D, SAWCHUK, M, HOCHMAN, S & LANDRY, ES. Evidence of a specific role for 5-HT2A and 5-HT7 receptors in hindlimb stepping generation induced pharmacologically in paraplegic mice, Soc. Neurosci. Abst. 30. (2004). [pdf]

MACHACEK, DW, HATCHER, M, SAWCHUK, M & HOCHMAN, S. Monoaminergic modulation of motor axon recurrent collateral pathways in the neonatal rat spinal cord, Soc. Neurosci. Abst. 30. (2004). [pdf]

WILLIAMS, KK, SUNDAR, K, HOCHMAN, S & DEWEERTH, S. Time and frequency domain evaluation of motor patterns evoked in the isolated neonatal rat spinal cord, Soc. Neurosci. Abst. 30. (2004). [pdf]

CUI D, DOUGHTERY K, SAWCHUK M, MACHACEK D, HOCHMAN S & BARO DJ. Expression profiling of identified spinal neurons before and after cord injury (SCI), Soc. Neurosci. Abst. 29. (2003). [pdf]

MACHACEK DW & HOCHMAN S. Monoaminergic modulation of synaptic pathways to motoneurons in the isolated rat spinal cord, Soc. Neurosci. Abst. 29.(2003). [pdf]

HOCHMAN S, SHEMESH S & SAWCHUK M. Forskolin increases differentiation of precursors into neurons in the isolated neonatal rat spinal cord in vitro, Soc. Neurosci. Abst. 29. (2003). [pdf]

SHAY B, SAWCHUK M & HOCHMAN S. Serotonin 5-HT2C receptor activation increases expression of PKCg and PKCz in an isolated rat spinal cord preparation, Soc. Neurosci. Abst. 29. (2003). [pdf]

DOUGHERTY KJ, SAWCHUK M & HOCHMAN S. Properties of GABAergic neurons in spinal cord lamina I of GAD67-EGFP expressing transgenic mice, Soc. Neurosci. Abst. 29. (2003). [pdf]

CLEMENS S, HUE G, SAWCHUK M, ZHU H & HOCHMAN S. Expression of dopamine D2 and D3 receptors and actions of dopaminergics on spinal circuits in wildtype and D3 knockout mice, Soc. Neurosci. Abst. 29. (2003). [pdf]