Home	Emory University School of Medicine Division of Pulmonary, Allergy and Critical Care Medicine Department of Cell Biology Atlanta, GA

Research Articles

• Goodson, P., A. Kumar, K. Kundu, N. Murthy, M. Koval, and M. N. Helms. 2012. NADPH oxidase regulates alveolar epithelial sodium channel (ENaC) activity and lung fluid balance in vivo via O2- signaling.. Amer. J. Physiol. Lung Cell. Mol. Biol., in press. (PubMed)


• Mitchell, L. A., C. E. Overgaard, C. Ward, S. S. Margulies and M. Koval. 2011. Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function, Amer. J. Physiol. Lung Cell. Mol. Biol., 301:L40-49 (PubMed)


• Koval, M., M. Billaud, A. C. Straub, A. Zarbock, B. R. Duling, B. E. Isakson, 2011. Spontaneous lung dysfunction and fibrosis in mice lacking connexin40 and endothelial cell connexin43, Amer. J. Path., 178:2536-2546. (PubMed)


• Fan, X., P. C. Joshi, M. Koval and D. M. Guidot. 2011. Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats, Alcohol. Clin. Exp. Res., 35:1866-1875.(PubMed)


• Su, V., R. Nakagawa, M. Koval, A.F. Lau. 2010. Ubiquitin-independent proteasomal degradation of ER-localized connexin43 mediated by CIP75. J Biol Chem. 285:40979-40990.(PubMed)


• Go Y.M., H. Park, M. Koval, M. Orr, M. Reed, Y. Liang, D. Smith, J. Pohl, D.P. Jones. 2010. A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential. Free Radic Biol Med. 48:275-283. (PubMed)


• Koval, M., C. Ward, M.K. Findley, S. Roser-Page, M. N. Helms, J. Roman. 2010. Extracellular matrix influences alveolar epithelial claudin expression and barrier function, Amer. J. Respir. Cell Mol. Biol., 175:1799-1801 (PubMed)


• Das, S., J. Das Sarma, J. D. Ritzenthaler, T. Smith, J. Maza, B. E. Kaplan, L. A. Cunningham, L. Suaud, R. C. Rubenstein, M. Koval. 2009. Regulation of connexin43 oligomerization and trafficking by ERp29, Mol. Biol. Cell, 20:2593-2604. (PubMed)


• Lassiter, C., X. Fan, P. C. Joshi, B. A. Jacob, R. L. Sutliff, D. P. Jones, M. Koval and D. M. Guidot. 2009. HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction. AIDS Research and Therapy, 6:1. (PubMed)


• Das Sarma, J., B. E. Kaplan, D. Willemsen and M. Koval. 2008. Identification of rab20 as a potential regulator of connexin43 trafficking. Cell Commun. and Adhesion, 15:65-74. (PubMed)


• Das Sarma, J., K. Iacono, L. Gard, L. Kenyon, M. Koval and S. R. Weiss. 2008. Demyelinating and non demyelinating strains of mouse hepatitis virus differ in their neural cell tropism. J. Virol. 82:5519-5526 (PubMed)


• Mrsny, R. J., G. T. Brown, , K. Gerner-Smidt, A. G. Buret, J. B. Meddings, C. Quan, M. Koval and A. Nusrat. 2008. A key claudin extracellular loop domain is critical for epithelial barrier integrity. Amer. J. Path., 172:905-915 (PubMed)


• Garnacho, C., V. Shuvaev, A. Thomas, L. MacKenna, M. Koval, S. Albelda, S. Muro and V. Muzykantov. 2008. Activation and recruitment of RhoA induced by anti-PECAM nanocarriers during CAM-mediated endocytosis: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Blood, 111:3024-3033 (PubMed)


• Laukoettor, M. G., P. Nava, W. Lee, C. Capaldo, E. Severson, B. Babbin, I. Williams, M. Koval, J. Campbell, T. Dermody, A. Nusrat, C. A. Parkos. 2007. JAM-A regulates mucosal permeability, claudin expression and intestinal inflammation in vivo. J. Exp. Med., 204:3067-3076 (PubMed)


• Daugherty, B.L., C. Ward, T. Smith, J. D. Ritzenthaler, M. Koval. 2007. Regulation of heterotypic claudin compatibility, J. Biol. Chem. 282:30005-30013 (PubMed)


• Fernandez, A. L., M. Koval, X. Fan and D. M. Guidot. 2007. Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats, Alcohol, 41:371-379 (PubMed)


• Blanchard-Fillion, B., M. Polydoro, D. Spielberg, Z. Wang, S. L. Hazen, M. Koval, and H. Ischiropoulos. 2006. Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells, J. Neurosci., 26:6124-6130 (PubMed)


• Muro S., M. Mateescu, C. Gajewski, M. Robinson, V. R. Muzykantov, M. Koval. 2006. Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ Exchanger (NHE) proteins. Am J Physiol Lung Cell Mol Physiol. 290:L809-817 (PubMed).


• Das Sarma, J., S. Das and M. Koval. 2005. Regulation of connexin43 oligomerization is saturable. Cell Commun. and Adhesion 12:237-247 (PubMed).


• Laing J.G., M. Koval, and T. H. Steinberg. 2005. Association with ZO-1 Correlates with Plasma Membrane Partitioning in Truncated Connexin45 Mutants. J Membr. Biol. 207:45-53 (PubMed).


• Fries D.M., R. Lightfoot, M. Koval and H. Ischiropoulos. 2005. Autologous Apoptotic Cell Engulfment Stimulates Chemokine Secretion by Vascular Smooth Muscle Cells. Am. J. Pathol. 167:345-353 (PubMed).


• Patel A.S., D. Reigada, C. H. Mitchell, S. R. Bates, S. S. Margulies and M. Koval. 2005. Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation. Am J Physiol Lung Cell Mol Physiol. 289:L489-496 (PubMed).


• Yoshino, A., S. R. Setty, C. Poynton, E. L. Whiteman, A. Saint-Pol, C. G. Burd, L. Johannes, E. L. Holzbaur, M. Koval, J. M. McCaffery and M. S. Marks. 2005 tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre. J. Cell Sci. 118:2279-2293.(PubMed).


• Maza, J., J. Das Sarma and M. Koval. 2005. Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J Biol Chem., 280:21115-21121 (PubMed).


• Muro, S., C. Gajewski, M. Koval and V. R. Muzykantov. 2005. ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs, Blood. 105:650-658.(PubMed).


• Daugherty, B., M. Mateescu, A. S. Patel, K. Wade, S. Kimura, L. W. Gonzales, P. L. Ballard and M. Koval. 2004. Developmental regulation of claudin localization by fetal alveolar epithelial cells, Amer. J. Physiol. Lung Cell. Mol. Biol., 287:L1266-1273 (PubMed).


• Lin, G.C., J.K. Rurangirwa, M. Koval, and T.H. Steinberg. 2004. Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells. J Cell Sci. 117:881-7.(PubMed).


• Maza, J., M. Mateescu, J.D. Sarma, and M. Koval. 2003. Differential oligomerization of endoplasmic reticulum-retained connexin43/connexin32 chimeras. Cell Commun Adhes. 10:319-22.(PubMed).


• Muro, S., X. Cui, C. Gajewski, J.C. Murciano, V.R. Muzykantov, and M. Koval. 2003. Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress. Am J Physiol Cell Physiol. 285:C1339-47.(PubMed).


• Wang, F., B. Daugherty, L. L. Keise, Z. Wei, J. P. Foley, R. C. Savani, and M. Koval. 2003. Heterogeneous claudin expression by alveolar epithelial cells. 2003. Amer. J. Respir. Cell Mol. Biol., 29:62-70. DOI 10.1165/rcmb.2002-0180OC(PubMed)


• Muro, S., R. Wiewrodt, L. Koniaris, A. P. Thomas, S. M. Albelda, V. Muzykantov and M. Koval. A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1. 2003. J. Cell Sci., 116:1599-1609 (PubMed)


• Das Sarma, J., E. Scheen, S. Seo, M. Koval and S. R. Weiss. 2002. Selection of a recombinant murine coronaviruses with efficient and stable expression of Enhanced Green Fluorescent Protein. J. Neurovirol. 8:381-91.(PubMed)


• Mulugeta, S., J. Gray, K. Notarfrancesco, L. W. Gonzales, M. Koval, S. I. Feinstein, P. L. Ballard, A. B. Fisher and H. Shuman. 2002. Identification of lbm180, a Lamellar Body Limiting Membrane Protein of Alveolar Type II Cells, as the ABC Transporter Protein, ABCA3. J. Biol. Chem.,277(25):22147-55. DOI 10.1074/jbc.M201812200 (PubMed)


• Das Sarma, J. F. Wang, and M. Koval. 2002. Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization. J. Biol. Chem., 277:20911-20918. DOI 10.1074/jbc.M111498200 (PubMed)


• Wiewrodt, R., A. P. Thomas, L. Cipelletti, D. A. Weitz, S. M. Albelda, M. Koval and V. Muzykantov. 2002. Size-dependent intracellular immunotargeting into endothelial cells via a surface adhesion molecule, PECAM-1. Blood, 99:912-922 (PubMed)


• Das Sarma, J., C. W. Lo and M. Koval. 2001. Cx43/b-gal inhibits Cx43 transport in the Golgi Apparatus. Cell Commun. Adhes., 8:249-252(PubMed)


• Das Sarma, J., R. I. Meyer, F. Wang, V. Abraham, C. W. Lo and M. Koval. 2001. Multimeric connexin interactions prior to the trans Golgi apparatus. J. Cell Sci., 114:4013-4024 (PubMed)


• Abraham, V., M. L. Chou, P. George, P. Pooler, A. Zaman, R. C. Savani and M. Koval. 2001. Heterocellular communication between alveolar epithelial cells. Amer. J. Phys. Lung Cell and Mol. Biol., 280:L1085-L1093. (PubMed)


• Laing, J. G., R. N. Manley-Markowski, M. Koval, R. Civitelli, and T. H. Steinberg. 2001. Connexin45 interacts with Zonula Occludens-1 and Connexin43 in Osteoblastic Cells. J. Biol. Chem, 276:23051-23055. (PubMed)


• Abraham, V., M. Chou, K. DeBolt and M. Koval 1999. Phenotypic control of gap junctional communication by alveolar epithelial cells. Amer. J. Phys. Lung Cell and Mol. Biol. 276:L825-834. (PubMed)


• Lecanda, F., D. A. Towler, K. Ziambaras, S.-L. Cheng, M. Koval, T. H. Steinberg & R, Civitelli. 1998. Gap junctional communication modulates gene expression in osteoblastic cells. Mol. Biol. Cell, 9:2249-2258. (PubMed)


• Koval, M., K. Preiter, C. Adles, P. D. Stahl, and T. H. Steinberg. 1998. Size of IgG-opsonized particles determines macrophage response during internalization. Exp. Cell Res., 242:265-273. (PubMed)


• Roach, T., S. Slater, M. Koval, L. White, E. Cahir-McFarland, M. Okamura, M. Thomas, and E. Brown. 1997. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr. Biol. 7:408-417. (PubMed)


• Koval, M., E. Hick, J. Harley, and T. H. Steinberg. 1997. Connexin46 is retained as monomers in a trans-Golgi compartment of osteoblastic cells. J. Cell Biol., 137:847-857. (PubMed)


• Koval, M., S. T. Geist, E. M. Westphale, A. E. Kemendy, R. Civitelli, E. C. Beyer and T. H. Steinberg. 1995. Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43. J. Cell Biol., 130:987-995. (PubMed)


• Treves, S., F. Larini, P. Menegazzi, T. H. Steinberg, M. Koval, B. Vilsen, and F. Zorzato. 1994. Alteration of intracellular Ca+2 transients in COS-7 cells transfected with cDNA encoding skeletal muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia. Biochem. J., 301:661-5. (PubMed)


• Diaz, R., M. I. Colombo, M. Koval, L. Mayorga, and P. Stahl. 1991. Endosomal density shift is related to a decrease in fusion capacity. Eur. J. Cell Biol. 56:223-232. (PubMed)


• Koval, M., and R. E. Pagano. 1990. Sorting of an internalized plasma membrane lipid between recycling and degradative pathways in normal and Niemann-Pick, type A fibroblasts. J. Cell Biol. 111:429-442. (PubMed)


• Palmer, R. E., M. Koval, and D. Koshland. 1989. The dynamics of chromosome movement in the budding yeast Saccharomyces cerevisiae. J. Cell Biol. 109:3355-3366. (PubMed)


• Koval, M., and R. E. Pagano. 1989. Lipid recycling between the plasma membrane and intracellular compartments: Transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts. J. Cell Biol. 108:2169-2181. (PubMed)


• Schwartz, D. C., and M. Koval. 1989. Conformational dynamics of individual DNA molecules during gel electrophoresis. Nature 338:520-522. (PubMed)


• Parry, G., E. Y.-H. Lee, D. Farson, M. Koval, and M. J. Bissell. 1985. Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells. Exp. Cell Res. 156:487-499. (PubMed)

Reviews and Chapters

• Ward, C. and M. Koval. 2011. Biochemical analysis of claudin binding compatibility. Methods Mol. Biology. 762:13-26.(PubMed)


• Overgaard, C.E., B. L.Daugherty, L.A. Mitchell and M. Koval. 2011. Claudins: Control of Barrier Function and Regulation in Response to Oxidant Stress. Antioxid Redox Signal. 15:1179-1193 (PubMed)


• Mitchell, L. A. and M. Koval. 2010. Specificity of Interaction between Clostridium perfringens Enterotoxin and Claudin-Family Tight Junction Proteins. Toxins (Basel). 2:1595-1611. (PubMed)


• Koval, M. 2010. Keratinocyte growth factor improves alveolar barrier function: keeping claudins in line. Am J Physiol Lung Cell Mol Physiol. 299:L721-723 (full article) (PubMed)


• Koval, M. 2009. Tight junctions, but not too tight: fine control of lung permeability by claudins. Am J Physiol Lung Cell Mol Physiol., 297:L217-218 (full article) (PubMed)


• Eaton, D.C., M. N. Helms, M. Koval, H. F. Bao, and L. Jain. 2009. The Contribution of Epithelial Sodium Channels to Alveolar Function in Health and Disease. Ann. Rev. Physiol., in press (PubMed)


• Findley, M.K. and M. Koval. 2009. Regulation and Roles for Claudin-Family Tight Junction Proteins. IUBMB Life, 61:431-437 (PubMed)


• Johnson, L. N. and M. Koval. 2009. Crosstalk between injury-stimulated signaling, oxidant stress and pulmonary gap junctional communication. Antioxid. Redox. Signal., 11:355-367 (PubMed)


• Koval, M., X. Fan, A. L. Fernandez, L. N. Johnson, P. C. Joshi, D. M. Guidot. 2008. Effects of alcohol and GM-CSF on alveolar tight junctions. Proc. Amer. Thoracic Soc., 5:368-369. - Proceedings of the Aspen Lung Conference


• Koval, M. 2008. Gap Junctions - Connexin Functions and Roles in Human Disease. in Cell Junctions: Adhesion, Development And Disease, Susan E. LaFlamme and Andrew Kowalczyk, editors, Wiley-VCH. pp 197-216.


• Bhattacharya, J., M. Koval and W. Kuebler. 2008. The Pulmonary Circulation. in Handbook of Physiology, Microcirculation, second edition. Ronald F. Tuma, Walter N. Duran and Klaus Ley, editors, Academic Press, pp 712-734.


• Koval, M. 2006. Claudins: key pieces in the tight junction puzzle. Cell Commun. Adhesion, 13:127-138 (PubMed)


• Koval, M. 2006. Pathways and control of connexin oligomerization. Trends Cell Biol. 16:159-166.(PubMed)


• Dzubila, T., S. Muro, V. R. Muzykantov and M. Koval. 2006. Nanoscale Anti-Oxidant Therapeutics. in Oxidative Stress, Disease and Cancer, Keshav K. Singh, editor. Imperial College Press, London, pp 1023-1044.


• Koval M. 2006. Connexins, tissue expression. in Encyclopedia of Respiratory Medicine, G. J. Laurent and S. D. Shapiro, editors. Elsevier, San Diego, CA., 558-560.


• Koval, M. and J. Bhattacharya. 2005. Vascular Gap Junctions. in Encyclopedia of the Microvasculature, David Shepro, editor. Elsevier, San Diego, CA.


• Boitano, S., Z. Safdar, D.G. Welsh,J. Bhattacharya and M. Koval. 2004. EB meeting report: Cell-cell interactions between lung cells. Amer. J. Physiol. Lung Cell and Mol. Biol., 287:L455-9 (PubMed)


• Muro, S., M. Koval and V. R. Muzykantov. 2004. Mechanisms for drug targeting to vascular endothelium. Curr. Vasc. Pharm., Curr. Vasc. Pharm. 2:281-299.(PubMed)


• Koval, M. 2002. Sharing signals: connecting lung epithelial cells with gap junctions. Amer. J. Physiol. Lung Cell and Mol. Biol. 283:L875-93.(PubMed)


• Abraham, V., K. DeBolt, R. Savani and M. Koval. 1999. Regulation of gap junction proteins by alveolar epithelial cells in response to injury. Chest, 35S. - Proceedings of the Aspen Lung Conference (PubMed)


• Koval, M., E. Hick, J. E. Harley and T. H. Steinberg. 1998. Cell-specific differences in transport and assembly of Connexin46. in Gap Junctions, R. Werner, ed. ISO Press, Amsterdam. 102-106.


• Koval, M., A. H. Futerman and R. E. Pagano. 1995. Sphingomyelin synthesis in endosomes? Trends. Cell Biol., 5:148-149.


• Koval, M. 1993. Plasma membrane lipid transport in cultured cells: Studies using lipid analogs and model systems. Adv. in Cell and Molec. Biol. of Membr. 1:199-224.


• Lenhard, J. M., M. I. Colombo, M. Koval, G. Li, L. S. Mayorga, and P. D. Stahl. 1993. Identification of proteins involved in endosome fusion: Implications for toxin activity. in Botulinium and Tetanus Neurotoxins: Neurotransmission and Biomedical Aspects. B. R. Das Gupta, ed. Plenum Publishing, N.Y. 120-132.


• Koval, M., and R. E. Pagano. 1991. Intracellular transport and metabolism of sphingomyelin. Biochim. Biophys. Acta 1082:113-125 (PubMed)


• Shero, J. H., M. Koval, F. Spencer, R. Palmer, P. Hieter, and D. Koshland. 1990. Analysis of Chromosome segregation in S. cerevisiae. Meth. Enz. 194:749-773. (PubMed)

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