Publications from the Emory Clinical Neuroscience Research Unit
Publications from the Emory Clinical Neuroscience Research Unit (ECNRU)
With accessible pdfs
only one copy of each publication can be printed which can only be used for educational purposes
- Nemeroff CB, Bremner JD, Foa EB, Mayberg HS, Nemeroff CB, North CS, Stein MB: Posttraumatic stress disorder: A state-of-the-science review. J Psychiatr Res 2006; 40(1):1-21.
- Bremner JD: Stress and brain atrophy. Current Drug Targets-Central Nervous System and Neurological Disorders. 2006; 5(5):503-512.
- Anda RF, Felitti VJ, Walker J, Whitfield C, Bremner JD, Perry BD, Dube SR, Giles WH: The enduring effects of childhood abuse and related experiences in childhood: A convergence of evidence from neurobiology and epidemiology. Eur Arch of Psychiatr Clin Neurosci 2006; 256(3):174-186.
- Schmahl CG, Bremner JD: Neuroimaging in borderline personality disorder. J Psychiatr Res 2006; 40(5):419-427.
- Vermetten E, Schmahl C, Lindner S, Loewenstein L, Bremner JD: Hippocampal and amygdala volume in dissociative identity disorder. Am J Psychiatry 2006; 163(4): 630-636.
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- Bremner JD, Quinn J, Quinn W, Veledar E: Surfing the net for medical information about psychological trauma: An empirical study of the quality and accuracy of trauma-related web sites. Med Inform Internet Med 2006; 31(3):227-236.
- Vasterling JJ, Bremner JD: The impact of the 1991 Gulf War on the mind and brain: findings from neuropsychological and neuroimaging research. Phil Trans Roy Soc Lond B Biol Sci 2006; 361 (1468):593-604.
- Vermetten E, Vythilingam M, Schmahl C, De Kloet C, Southwick WM, Charney DS, Bremner JD: Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder. Ann NY Acad Sci. 2006; 1071:184-202.
- Bremner JD: Relationship between cognitive and brain changes in posttraumatic stress disorder (PTSD). Annal NY Acad Sci 2006; 1071:80-86.
- Bremner JD, Vythilingam M, Vermetten E, Newcomer JW, Charney DS: Effects of dexamethasone on declarative memory function in posttraumatic stress disorder (PTSD). Psychiatry Res 2005; 129(1):1-10.
- Bremner JD, Vermetten E, Schmahl C, Vaccarino V, Vythilingam M, Afzal N, Grillon C, Charney DS: Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual abuse-related posttraumatic stress disorder. Psychol Med 2005; 35(6):791-806.
- Elzinga BM, Bakker A, Bremner JD: Stress-induced cortisol elevations are associated with impaired delayed, but not immediate recall. Psychiatry Res 2005; 134(3):211-223.
- Bremner JD, Mletzko T, Welter S, Quinn S, Williams C, Brummer M, Siddiq S, Reed L, Heim CM, Nemeroff CB: Effects of phenytoin on memory, cognition and brain structure in posttraumatic stress disorder: A pilot study. J Psychopharmacol 2005; 19(2):159-165.
- Jarkas N, Votaw JR, Voll RJ, Williams L, Camp VM, Owens MJ, Purselle DC, Bremner JD, Kilts CD, Nemeroff CB, Goodman MM: Carbon-11 HOMADAM: A novel PET radiotracer for imaging serotonin transporters. Nuc Med Biol 2005; 32:211-224.
- Bremner JD, Fani N, Ashraf A, Votaw JR, Brummer ME, Cummins T, Vaccarino V, Goodman MM, Reed R, Siddiq S, Nemeroff CB. Functional brain imaging alterations in acne patients treated with isotretinoin. Am J Psychiatry 2005; 162:983-991.
- Vythilingam M, Luckenbaugh D, Lam T, Morgan CA, Lipschitz D, Charney DS, Bremner JD, Southwick SM: Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder. Psychiatry Res 2005; 139(2):89-99.
- Bremner JD: Effects of traumatic stress on brain structure and function: Relevance to early responses to trauma. J Trauma Dissociation 2005; 6(2):51-68.
- Geuze E, Vermetten E, Bremner JD: MR based in vivo hippocampal volumetrics: I. Review of methodologies currently employed. Mol Psychiatry 2005; 10:147-159.
- Geuze E, Vermetten E, Bremner JD: MR based in vivo hippocampal volumetrics: II. Findings in neuropsychiatric disorders. Mol Psychiatry 2005; 10:160-184.
- Hogue CJ, Bremner JD: Stress model for research into preterm delivery among black women. Am J Obstet Gynecol 2005; 192(5 Suppl):S47-55.
- Evans DL, Charney DS, Lewis L, Golden RN, Gorman JM, Krishnan KRR, Nemeroff CB, Bremner JD, Carney RM, Coyne JC, DeLong MR, Frasure-Smith N, Glassman AH, Gold PW, Grant I, Gwyther L, Ironson G, Johnson RL, Kanner AM, Katon WJ, Kaufmann PG, Keefe FJ, Ketter T, Laughren TP, Leserman J, Lyketsos CG, McDonald WM, McEwen BS, Miller AH, Musselman D, O’Connor C, Petitto JM, Pollock BG, Robinson RG, Roose SP, Rowland J, Sheline Y, Sheps DS, Simon G, Spiegel D, Stunkard A, Sunderland T, Tibbits P, Valvo WJ: Mood disorders in the medically ill: Scientific review and recommendations. Biol Psychiatry 2005; 58 (3):175-189.
- Bremner JD: Changes in brain volume in major depression. Depression: Mind and Brain. 2005; 2 (2): 38-46.
- Vaccarino V, Bremner JD: Stress response and the metabolic syndrome. Hospital Physician Board Review Manual: Cardiology 2005; 11:1-12.
- Kitayama N, Vaccarino V, Kutner M, Weiss P, Bremner JD: Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis. J Affective Disorders 2005; 88(1):79-86.
- Vermetten E, Bremner JD: Functional brain imaging and the induction of traumatic recall: A cross-correlational review between neuroimaging and hypnosis. Int J Clin Exp Hypnosis 2004; 52(3):280-312.
- Bremner JD: Does stress damage the brain: Understanding trauma related disorders from a mind body perspective. Directions in Psychiatry 2004; 24(3):167-176
- Bremner JD, Vermetten E: Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorder (PTSD). Ann NY Acad Sci 2004; 1032:154-157.
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Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, Staib LH, Charney DS, Bremner JD: Hippocampal volume, memory and cortisol status in major depressive disorder: Effects of treatment. Biol Psychiatry 2004; 56:101-112.
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Bremner JD: Brain imaging in anxiety disorders. Expert Rev Neurotherapeutics 2004; 4 (2): 275-284.
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Schmahl CG, Elzinga B, Ebner U, Haaf B, Sanislow C, McGlashan TH, Bremner JD: Psychophysiological reactivity to traumatic and abandonment scripts in borderline personality disorder and posttraumatic stress disorder: A preliminary report. Psych Res 2004; 126 (1):33-42.
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Schmahl CG, Vermetten E, Elzinga BE, Bremner JD: A positron emission tomography study of memories of childhood abuse in borderline personality disorder. Biol Psychiatry 2004: 55(7):759-765.
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Bremner JD, Vythilingam M, Vermetten E, Newcomer JW, Charney DS: Effects of glucocorticoids on declarative memory function in major depression. Biol Psychiatry 2004; 55 (8):811-815.
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Bremner JD, Vythilingam M, Vermetten E, Charney DS: Deficits in hippocampal and anterior cingulate function during verbal declarative memory encoding in mid-life major depression. Am J Psychiatry 2004; 161 (4): 637-645.
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Bremner JD, Vermetten E, Vythilingam M, Afzal N, Schmahl C, Elzinga B, Charney CS: Neural correlates of the classical color and emotional Stroop in women with abuse-related posttraumatic stress disorder. Biol Psychiatry 2004; 55 (6):612-620.
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Vermetten E, Bremner JD: Functional brain imaging and the induction of traumatic recall: A cross-correlational review between neuroimaging and hypnosis. Int J Clin Exp Hypnosis 2004; 52(3):280-312.
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Bremner JD, Vythilingam M, Ng CK, Vermetten E, Nazeer A, Oren D, Berman RM, Charney DS: Regional brain metabolic correlates of a-methylparatyrosine-induced depressive symptoms: Implications for the neural circuitry of depression. JAMA 2003; 289:3125-3134.
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Bremner JD: Does isotretinoin cause depression and suicide? Psychopharmacol Bull 2003; 37:5:9.
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Schmahl CG, Elzinga BM, Vermetten E, Sanislow C, McGlashan TH, Bremner JD: Neural correlates of memories of abandonment in women with and without borderline personality disorder. Biol Psychiatry 2003; 54:142-151.
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Vermetten E, Bremner JD: Olfaction as a traumatic reminder in posttraumatic stress disorder: Case reports and review. J Clin Psychiatry 2003; 64 (2):202-207.
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Davis MR, Votaw JR, Bremner JD, Byas-Smith MG, Faber TL, Voll RJ, Watts RL, Hoffman JM, Grafton, ST, Kilts CD, Goodman MM: Initial PET imaging studies with the dopamine transporter ligand [18F]FECNT. J Nucl Med 2003; 44:855-861.
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Schmahl CG, Vermetten E, Elzinga BM, Bremner JD: Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder. Psych Research: Neuroimaging 2003; 122: 193-198.
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Elzinga BM, Schmahl CS, Vermetten E, van Dyck R, Bremner JD: Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology 2003; 28 (9):1656-1665.
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Juengling F, Schmahl C, Hesslinger B, Eberg D, Bremner JD, Gostomzyk M, Bohus M, Libe K: Positron emission tomography in female patients with borderline personality disorder. J Psychiatric Research 2003; 37:109-115.
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Bremner JD: Functional neuroanatomical correlates of traumatic stress revisited 7 years later, this time with data. Psychopharmacol Bull 2003; 37 (2):6-25.
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Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib L, Soufer R, Charney DS: Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder (PTSD) related to early childhood sexual abuse. Biol Psychiatry 2003; 53:289-299.
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Bremner JD, Vythilingam M, Vermetten E, Adil J, Khan S, Nazeer A, Afzal N, McGlashan T, Anderson G, Heninger G, Southwick SM, Charney DS: Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology 2003; 28:733-750.
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Vythilingam M, Chen J, Bremner JD, Mazure CM, Maciejewski PK, Nelson JC: Psychotic depression and mortality. Am J Psychiatry 2003; 160:574-576.
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Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, Khan S, Vaccarino LV, Soufer R, Garg P, Ng CK, Staib LH, Duncan JS, Charney DS: MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder (PTSD). Am J Psychiatry 2003; 160:924-932, 2003.
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Bremner JD: Long-term effects of childhood abuse on brain and neurobiology. Child and Adolescent Psych Clin N America 2003; 12(2):271-292
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Vermetten E, Vythilingam M, Southwick SM, Charney DS, Bremner JD: Long- term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol Psychiatry 2003; 54 (7):693-702.
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Vythilingam M, Heim C, Newport CD, Miller AH, Vermetten E, Anderson E, Bronen R, Brummer M, Staib L, Charney DS, Nemeroff CB, Bremner JD: Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 2002; 159:2072-2080.
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Bremner JD: Neuroimaging studies in posttraumatic stress disorder. Current Psych Reports 2002; 4:254-263.
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Booij L, Van der Does W, Benkelfat C, Bremner JD, Cowen PJ, Fava M, Gillin C, Leyton M, Moore P, Smith KA, Van der Kloot WA: Predictors of mood response to acute tryptophan depletion: A reanalysis. Neuropsychopharmacology 2002; 27:852-861.
- Bremner JD, Soufer R, McCarthy G, Delaney R, Staib LH, Duncan JS, Charney DS: Gender differences in cognitive and neural correlates of remembrance of emotional words. Psychopharmacol Bull. 2001;35:55-87.
- Bremner JD, Vermetten E: Stress and development: Behavioral and biological consequences. Dev Psychopathol 2001; 13:473-489.
- Bremner JD, Horti A, Staib LH, Zea-Ponce Y, Soufer R, Charney DS, Baldwin R: Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]iomazenil in healthy human subjects. Synapse 2000; 35:68-77.
- Bremner JD, Narayan M, Anderson ER, Staib LH, Miller H, Charney DS:
Hippocampal volume reduction in major depression. Am J Psychiatry 2000; 157:115-117.
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Bremner JD, Innis RB, White T, Fujita M, Silbersweig D, Goddard AW, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney DS: SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biol. Psychiatry. 2000; 47:96-106.
- Bremner JD, Vermetten E, Mazure CM: Development and preliminary psychometric properties of an instrument for the measurement of childhood trauma: The Early Trauma Inventory. Depress Anxiety 2000;12:1-12.
- Bremner JD, Innis RB, Southwick SM, Staib LH, Zoghbi S, Charney DS: Decreased benzodiazepine receptor binding in frontal cortex in combat-related posttraumatic stress disorder. Am J Psychiatry. 2000;157:1120-1126.
- Bremner JD, Shobe KK, Kihlstrom JF: False memories in women with self-reported childhood sexual abuse: An empirical study. Psychol Sci 2000; 11:333-337.
- Vythilingam M, Anderson E, Goddard A, Woods SW, Staib LH, Charney DS, Bremner JD: Temporal lobe volumes in panic disorder—a quantitative magnetic resonance imaging study. Psychiatry Research: Neuroimaging 2000; 99:75-82.
- Bremner JD: Does stress damage the brain? Biol Psychiatry 1999; 45:797-805.
- Bremner JD, Staib L, Kaloupek D, Southwick SM, Soufer R, Charney DS: Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder (PTSD): A positron emission tomography study. Biol. Psychiatry. 1999; 45:806-816.
- Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS: Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 1999; 156:1787-1795.
- Bremner JD, Baldwin R, Horti A, Staib LH, Ng CK, Tan P-Z, Zea-Ponce Y, Zoghbi S, Seibyl JP, Soufer R, Charney DS, Innis RB: Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: Preliminary results of a direct comparison in healthy human subjects. Psych Res: Neuroimaging 1999; 91:79-91.
- Bremner JD, Krystal JH, Putnam F, Marmar C, Southwick SM, Lubin H, Charney DS, Mazure CM: Measurement of dissociative states with the Clinician Administered Dissociative States Scale (CADSS). J. Trauma. Stress 1998; 11:125-136.
- Soufer R, Bremner JD, Arrighi JA, Cohen I, Zaret BL, Burg MM, Goldman-Rakic P: Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. P.N.A.S. 1998; 95:6454-6459.
- Bremner JD, Bronen RA, de Erasquin G, Vermetten E, Staib L, Ng CK, Soufer R, Charney DS, Innis RB: Development and reliability of a method for using magnetic resonance imaging for the definition of regions of interest for positron emission tomography. Clin. Positron Imaging 1998; 1:145-159.
- Bremner JD, Southwick SM, Darnell A, Charney DS: Chronic PTSD in Vietnam combat veterans: Course of illness and substance abuse. Am. J. Psychiatry. 1996;153:369-375.
- Bremner JD, Brett E: Trauma-related dissociative states and long-term psychopathology in posttraumatic stress disorder. J. Trauma. Stress. 1997; 10:37-50.
- Bremner JD, Randall P, Vermetten E, Staib L, Bronen RA, Capelli S, Mazure CM, McCarthy G, Innis RB, Charney DS: MRI-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse: A preliminary report. Biol. Psychiatry 1997;41:23-32.
- Bremner JD, Innis RB, Ng CK, Staib L, Duncan J, Bronen R, Zubal G, Rich D, Krystal JH, Dey H, Soufer R, Charney DS: PET measurement of cerebral metabolic correlates of yohimbine administration in posttraumatic stress disorder. Arch. Gen. Psychiatry. 1997; 54:246-256.
- Bremner JD, Innis RB, Salomon RM, Staib L, Ng CK, Miller HL, Bronen RA, Duncan J, Krystal JH, Rich D, Malison R, Price LH, Dey H, Soufer R, Charney DS: PET measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Arch. Gen. Psychiatry. 1997; 54:364-374.
- Bremner JD, Licinio J, Darnell A, Krystal JH, Owens M, Southwick SM, Nemeroff CB, Charney DS: Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. Am. J. Psychiatry. 1997; 154:624-629.
- Bremner JD, Southwick SM, Darnell A, Charney DS: Chronic PTSD in Vietnam combat veterans: Course of illness and substance abuse. Am. J. Psychiatry. 1996;153:369-375.
- Bremner JD, Krystal JH, Southwick SM, Charney DS: Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies. Synapse 1996; 23:28-38.
- Bremner JD, Krystal JH, Southwick SM, Charney DS: Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 1996; 23:39-51.
- Bremner JD, Krystal JH, Charney DS, Southwick SM: Neural mechanisms in dissociative amnesia for childhood abuse: Relevance to the current controversy surrounding the False Memory Syndrome. Am. J. Psychiatry. 1996;153(7):FS71-82.
- Bremner JD, Randall P, Scott TM, Bronen RA, Delaney RC, Seibyl JP, Southwick SM, McCarthy G, Charney DS, Innis, RB: MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am. J. Psychiatry 1995; 152:973-981.
- Bremner JD, Randall PR, Capelli S, Scott T, McCarthy G, Charney DS: Deficits in short-term memory in adult survivors of childhood abuse. Psych. Res. 1995; 59:97-107.
- Yehuda R, Southwick SM, Krystal JH, Bremner JD, Charney DS, Mason J: Enhanced suppression of cortisol with low dose dexamethasone in posttraumatic stress disorder. Am. J. Psychiatry. 1993;150:83-86.
- Bremner JD, Southwick SM, Johnson DR, Yehuda R, Charney DS: Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. Am. J. Psychiatry. 1993;150:235-239.
- Bremner JD, Steinberg M, Southwick SM, Johnson DR, Charney DS: Use of the Structured Clinical Interview for DSMIV-Dissociative Disorders for systematic assessment of dissociative symptoms in posttraumatic stress disorder. Am. J. Psychiatry. 1993;150:1011-1014.
- Bremner JD, Scott TM, Delaney RC, Southwick SM, Mason JW, Johnson DR, Innis RB, McCarthy G, Charney DS: Deficits in short-term memory in post-traumatic stress disorder. Am. J. Psychiatry. 1993;150:1015-1019.
- Bremner JD, Southwick SM, Rosenheck R, Brett E, Fontana A, Charney DS: Dissociation and posttraumatic stress disorder in Vietnam combat veterans. Am. J. Psychiatry. 1992;149(3):328-332.