Research Focus

Investigations in vascular biology to further understand the contribution of oxidative stress and chronic infections to the process of atherosclerosis. Further characterization of the vascular and phagocytic NAD(P)H oxidases in order to investigate a possible role of genetic polymorphisms in atherogenesis, and with severity and extent of coronary atherosclerosis in subjects with and without coronary artery disease.

Research Posters

DUDLEY, S.C., Jr., S.K. ZARTER, V. HEGGEN, P. WILSON, R.A. TAYLOR, M. STERNBERG, A.M. ZAFARI. Improved Resuscitation Efficacy with a Program Emphasizing In-Hospital Early Defibrillation.
(Adobe PDF File Size: 400 KB)

RAO, SWAPNA, SHEIKH, ABDUL, AUSTIN, HARLAND, CHOUDHARY, GAURAV, ZAFARI, A. MAZIAR. The Endothelial Nitric Oxide Gene Polymorphism Does Not Predict Severity of Coronary Artery Disease.
(Adobe PDF File Size: 111 KB)

Active Grant Support

Private foundation funded:
1999-2001, P.I., Emory University Research Committee, p22phox Polymorphisms of the NAD(P)H Oxidase in Patients With and Without Coronary Heart Disease: A Novel Coronary Risk Factor? Research Award.

2001-2003, P.I., American Heart Association-Southeast Affiliate, The Effect of p22phox Genotypes on Phagocytic Respiratory Burst Activity in Young Adults without Coronary Artery Disease, Beginning Grant-In-Aid.

Industry funded:
2000-2001, P.I. for the VAMC Atlanta site: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Hemodynamic and Clinical Effects of Natrecor (nesiritide) Compared with Nitroglycerin Therapy for Symptomatic Decompensated CHF, SCIOS.

2001-2002, P.I. for the VAMC Atlanta site: Prospective Randomized Outcomes Study of Acutely Decompensated CHF Treated Initially in Outpatients With Natrecor: The PROACTION Trial, SCIOS.

2001-2004, Co-Investigator for the VAMC Atlanta site: A Clinical Evaluation Comparing Tc-99m TEBOROXIME and Tc-99m SESTAMIBI With Pharmacologic Stress as Well as Coronary Angiography in Patients With and Without Coronary Artery Disease, CardioTec.

2002, educational grant for the Emory/VAMC Division of Cardiology to teach coronary anatomy and techniques of left and right heart catheterization and coronary angiography on custom-made anatomical models to cardiology fellows, medical residents and students. Pfizer Inc.