Recent Publications

Menthol shares general anesthetic activity and sites of action on the GABA A receptor with the intravenous agent, propofol. European Journal of Pharmacology (2008) in press Watt EE, Betts BA, Kotey FO, Humbert DJ, Griffith TN, Kelly EW, Veneskey KC, Gil N, Rowan KC, Jenkins A, & Hall AC. PubMed

Inhaled anesthetics do not combine to produce synergistic effects regarding MAC in rats. Anesthesia & Analgesia (2008) Aug;107(2):479-85Eger EI II, Tang M, Liao M, Laster M, Solt K, Flood P, Jenkins A, Raines DE, Hendrickx JFA, Shafer SL, Yasumasa T, Sonner JM PubMed

General anesthetics have additive actions on three ligand gated ion channels. Anesthesia & Analgesia (2008) Aug;107(2):486-93Jenkins A, Lobo IA, Gong D, Trudell JR. Solt K, Harris RA and Eger EI II PubMed

Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn 2+ in GABA(A) alpha beta receptors and provides a structural basis for the modulating effect of the gamma subunit. J Chem Inf Model (2008) 48 :344-9 Trudell JR, Yue ME, Bertaccini EJ, Jenkins A, Harrison NL PubMed

A conserved tyrosine in the beta 2 subunit M4 segment is a determinant of g-aminobutyric acid type A receptor sensitivity to propofol. Anesthesiology, (2007) 107 :412-8 Richardson JE, Garcia PA, O'Toole KK, Derry MC, Bell SV & Jenkins A PubMed

Additive actions of sevoflurane and propofol on g-aminobutyric acid receptor function. Anesthesiology (2006) 104 : 1176-83 Sebel LE, Richardson JE, Singh SP, Bell SV & Jenkins A PubMed

A gain-of-function mutation in the GABA A receptor produces synaptic and behavioral abnormalities in the mouse. Genes, Brain and Behavior (2005) 4: 10-19 Homanics G, Elsen FP, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Ying S-W, Goldstein PA, Kralic J, Morrow AL & Harrison NL PubMed

A highly conserved aspartic acid residue in the signature disulfide-loop of the alpha 1 subunit is a determinant of gating in the glycine receptor. J. Biol.Chem (2003) 278(36): 34079-83 Schofield CM, Jenkins A, & Harrison, NL PubMed