Curriculum Vitae

1984 Sc.B. Brown University (Neural Science), Providence, RI

1984 Sc.B. Brown University (Experimental Psychology; Honors), Providence, RI

1992 Ph.D. Emory University School of Medicine (Neuroscience, Pharmacology), Atlanta, GA

1980-84: Research Assistant, Departments of Biology and Genetics, Brown University, Providence, RI

1983-84: Volunteer Research Assistant, Butler Mental Institute, Providence, RI

1984-86: Research Specialist, Department of Pharmacology, Emory University School of Medicine, Atlanta, GA

1986-92: Graduate Fellow, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA

1992-95: Postdoctoral Fellow, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA

1995-99: Research Associate, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA

1999-Present: Assistant Professor, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA

Board of Directors, Georgia Affiliate of the Foundation Fighting Blindness

Association for Research in Vision and Ophthalmology

International Society for Eye Research

American Association for the Advancement of Science

Society for Neuroscience

1994-Present: Founder and Senior Editor, Molecular Vision, http://www.molvis.org/

1994-Present: Editorial Review Board, International Journal of Molecular Sciences

2000-Present: Fellowship Grants Review Committee, Foundation Fighting Blindness

2001-Present: Symposium moderator and organizer (ARVO 2002) - "Oligonucleotide-mediated gene manipulation in the eye"

Ad-hoc reviewer: Journal of Neurochemistry, Investigative Ophthalmology and Vision Science, Visual Neuroscience, FEBS Letters, Brain Research

1995-1999: Lecturer, COMT 530 Pgm in Ophthal Tech, Dept. of Ophthal., Emory University

1999-Present: Lecturer, Biology 475/IBS 548 - Biology of the Eye, Emory University

1999-Present: Mentor, Howard Hughes Science Initiatives, Emory University

2001-Present: Mentor, Georgia Internship for Teachers (GIFT) program, Emory University

2001-Present: Lead Instructor, IBS 570r Topics in Molecular Biology and Genetics, Emory University Graduate School of Arts and Sciences

2001-Present: Dissertation Advisor, BIO 540 Undergraduate Honors Research, Emory University Graduate School of Arts and Sciences

2002-Present: Doctoral Thesis Supervisor, Eva Stodulkova, Departments of Plant Physiology Molecular Biology, Charles University, Prague, Czech Republic

Departmental and University Service

1999-Present: NEI Core Grant Committee, Department of Ophthalmology, Emory University

1999-Present: NEI Training Grant Committee, Department of Ophthalmol., Emory University

2000-Present: Provost's Digital Futures Group, Emory University

2001-Present: Long Range Planning Committee, Department of Ophthalmol., Emory University

2001-Present: Chairman, Information Technologies Committee, Dept. of Ophthal., Emory Univ.

2001-Present: Harris Chair Faculty Search Committee, Dept. of Ophthalmol., Emory Univ.

2001-Present: Director, The Vision Research Seminar, Dept. of Ophthalmology, Emory University and the Veteran’s Administration Rehabilitation Research and Development Center

Funding and Recognition

1980: Scholastic Grant, English Speaking Union

1986-89: Robert B. Woodruff Predoctoral Fellowship, Emory University

1988: Travel Award, International Congress of Eye Research, ICER

1989-91: Advanced Predoctoral Fellowship in Pharmacology, Pharmaceutical Manufacturers Association Foundation

1990: Grant-In-Aid, Sigma Xi

1992: Training Grant for Multidisciplinary Training in Vision Research, NEI, NIH

1992-95: Postdoctoral Fellowship, National Research Service Award, NEI, NIH

1994: Travel Fellowship Grant, ARVO Annual Meeting, Retina Research Foundation/Lawrence Fund

1995-96: Fight-for-Sight Grant-in-Aid

1997-98: Departmental Research Award, Department of Ophthalmology, Emory University

National Eye Institute, NIH (Boatright, PI) 6/01/99-Present
R01 EY12514 Permissive retinal gene expression via hypomethylation

CIBA Vision Ophthalmics (Boatright, PI) 11/0198-Present
Unrestricted Development Award

Georgia Knights Templar Education Foundation (Boatright, PI) 4/01/99-Present
Unrestricted Development Award

National Eye Institute, NIH (Boatright, Co-PI; Nickerson, PI) 9/30/97-Present
R01 EY09378 IRBP Gene Expression in the Retina

Foundation Fighting Blindness (Boatright, Module Dir; Sternberg, PI) 8/01/99-Present
Retinal Degenerations Research Center Grant

Publications

1. Iuvone, P.M., Boatright, J.H., and Bloom, M.M. Dopamine mediates the light-evoked suppression of serotonin N-acetyltransferase activity in retina. Brain Res. 418:314-324, 1987.

2. Iuvone, P.M. and Boatright, J.H. Stimulation of dopamine synthesis, release, and metabolism in the retina by exogenous tetrahydrobiopterin. In Pteridines and Biogenic Amines in Neuropsychiatry, Pediatrics, and Immunology (R.A. Levine, S. Milstien, D.H. Kuhn, and H. Ch. Curtius, eds.), Lakeshore Publishing, Grosse Point, pp. 273-284, 1989.

3. Boatright, J.H., Hoel, M.J., and Iuvone, P.M. Stimulation of endogenous dopamine release and metabolism by light and K+-evoked depolarization. Brain Res. 482:164-168, 1989.

4. Boatright, J.H. and Iuvone, P.M. GABA and the regulation of serotonin N-acetyltransferase activity in amphibian retina I.: Effects of GABA agonists and antagonists. Neurochem. Internat. 15(4):541-547, 1989.

5. Boatright, J.H. and Iuvone, P.M. GABA and the regulation of serotonin N-acetyltransferase activity in amphibian retina II.: The role of dopamine. Neurochem. Internat. 15(4):549-554, 1989.

6. Boatright, J. H., Gordon, J.R., and Iuvone, P.M. Inhibition of endogenous dopamine release in amphibian retina by L-2-amino-4-phosphonobutyric acid (L-AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD). Brain Res. 649:339-342, 1994.

7. Boatright, J. H., Rubim, N.M., and Iuvone, P.M. Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine. Vis. Neurosci. 11:1003-1012, 1994.

8. Boatright, J. H., Rubim, N.M., and Iuvone, P.M. Regulation of endogenous dopamine release in amphibian retina by melatonin: The role of GABA. Vis. Neurosci. 11:1013-1018, 1994.

9. Nickerson, J.M., Mody, V., DeGuzman, C., Heron, K.A., Marciante, K., Boatright, J., Si, J.S., and Lin, Z.Y. Ligand-binding properties of recombinant human IRBP. In Degenerative Diseases of the Retina (Anderson, R.E., Lavail, M., and Holleyfield, J. eds.) Plenum, New York, pp. 395-402, 1995.

10. Boatright J.H., Nickerson J.M., Church R.L. Electronic Publishing. Science 270(5234):217-218 (Letter), 1995.

11. Boatright, J.H., Peoples, J.W., Buono, R.J., Bruno. J., Lang, R.K., Si, J.-S., and Nickerson, J.M. The 5' flanking regions of IRBP and arrestin have promoter activity in primary embryonic chicken retina cell cultures. Exp. Eye Res. 64:269-277, 1997.

12. Saperstein, D. S. and Boatright, J.H. Gene therapy and its potential role for age related macular degeneration. Sem. Ophthalmol. 12:4-9, 1997.

13. Boatright, J.H., Borst, D.E., Peoples J.W., Bruno J., Edwards C.L., Si J.-S., and Nickerson, J.M. A major cis activator of the IRBP gene contains CRX-binding and Ret-1/PCE-I elements. Mol.Vis. 3:15-22, 1997.

14. Boatright, J.H. , Gross, E.A., Peoples, J.W., and Nickerson, J.M. An inexpensive low-temperature incubator. W3 J. Biol. 3:3, 1998.

15. Boatright, J.H., Irony: The Spice of (Online) Life. Science 287(5456): 1203 (Letter), 2000.

16. Gross, E.A., Li, G.R., Lin, Z.Y., Ruuska, S.E., Boatright, J.H., Mian, S., and Nickerson, J.M. Prediction of structural and functional relationships of Repeat 1 of human interphotoreceptor retinoid-binding protein (IRBP) with other proteins. Mol.Vis. 6:30-39, 2000.

17. Gross, E.A., Li, G.R., Ruuska, S.E., Boatright, J.H., and Nickerson, J.M. Effects of dispersed point substitutions in Repeat 1 of human interphotoreceptor retinoid binding protein (IRBP). Mol.Vis. 6:40-50, 2000.

18. Gross, E.A., Li, G.R., Lin, Z.Y., Ruuska, S.E., Boatright, J.H., I. Mian, S., and Nickerson, J.M. G239T mutation in Repeat 1 of human IRBP: Possible implications for more than one binding site in a single repeat. Mol.Vis. 6:51-66, 2000.

19. Boatright JH, Nickerson JM, Borst DE. Site-specific DNA hypomethylation permits expression of the IRBP gene. Brain Res. 2000;887(1):211-221.

20. Dodson CS, Rengarajan K, Gewant HD, Stodulkova E, Nguyen HT, Boatright, JH, Nickerson JM. Extra-Hepatic expression of serum albumin mRNA in mouse retina. Curr Eye Res. 22(3):182-9, 2001.

21. Boatright JH, Knox BE, Jones, KM, Stodulkova E, Nguyen HT, Padove, SA, Borst, DE, Nickerson JM. Evidence of a tissue-restricting DNA regulatory element in the mouse IRBP promoter. FEBS Lett. 504: 27-30, 2001.

22. Boatright JH, Borst DE, Stodulkova, E, Nickerson JM. Endogenous CRX expression and IRBP promoter activity in retinoblastoma cells. Brain Res. 916: 136-142, 2001.

23. Borst DE, Boatright JH, Si J-S, Stodulkova, E, Gewant HD, Remaley N, Pallansch LA, Nickerson JM. Structural characterization and comparison of promoter activity of mouse and bovine interphotoreceptor retinoid-binding protein (IRBP) gene 5' flanking regions in WERI, Y79, chick retina cells, and transgenic mice. Curr Eye Res. 23(1): 20-32.

24. Boatright JH, Stodulkova E, Do VT, Padove SA, Nguyen HT, Borst DE, Nickerson JM. The effect of retinoids and butyrate on the expression of CRX and IRBP in retinoblastoma cells. Vis. Res. 42: 933-938, 2002.

[25.] Li J, Boatright JH, Wartell, RM. RNA/DNA hybrid formation and cleavage with stable hairpin DNA oligomers in antisense gene therapy. In preparation.

Abstracts and Presentations

1. Boatright, J.H., Hoel, M.J., and Iuvone, P.M. Evidence that light stimulates endogenous dopamine release and metabolism in retinas of frogs (Xenopus laevis). Soc. Neurosci. Abst. 13: 1298, 1987.

2. Iuvone, P.M., Boatright, J.H., Zawilska,J., and Avendano, G. Dopamine in amacrine cells: Light-evoked release and metabolism, and role in melatonin synthesis. Proc. Internat. Soc. Eye Res. 5: 76,1988.

3. Boatright, J.H. and Iuvone, P.M. Melatonin suppresses the light-evoked release of endogenous dopamine from retinas of frogs (Xenopus laevis). Soc. Neurosci. Abst. 15: 1395, 1989.

4. Boatright, J.H. and Iuvone, P.M. Regulation of dopamine release from frog retina by GABA agonists and antagonists. Invest. Ophthalmol. Vis. Sci. 31(4): 334, 1990.

5. Boatright, J.H., Gan J., Butler, B.J., Avendano, G., and Iuvone, P.M. MDL 12,330A, an inhibitor of adenylate cyclase activity, inhibits induction of serotonin N-acetyltransferase activity in retina and pineal gland. FASEBJ 5: A 1499, 1991.

6. Boatright, J.H. and Iuvone, P.M. Multiple inhibitory modulators of dopamine release in frog retina. Invest. Ophthalmol. Vis. Sci. 32:1261, 1991.

7. Boatright, J.H., Gordon, J.R., and Iuvone, P.M. 2-Amino-4-phoshonobutyric acid (AP-4) blocks light-evoked dopamine release in frog retina. Invest. Ophthalmol. Vis. Sci. 33(4): 1405, 1992.

8. Rubim, N.M., Boatright, J.H., Gordon, J.R., and Iuvone, P.M. NMDA receptors regulate dopamine release in amphibian retina. Invest. Ophthalmol. Vis. Sci. 34(4): 1063, 1993.

9. Boatright, J.H., Ram, H., and Nickerson, J. Protein and DNA complexes in the distal 5' flanking region of the IRBP gene. Invest. Ophthalmol. Vis. Sci. 34(4): 830, 1993.

10. Boatright, J.B., Borst, D.E., Nagpal, S., Ram, H., and Nickerson, J.M. Characterization of trans-acting factors and cis-acting elements in the IRBP gene. Invest. Ophthalmol. Vis. Sci. 35(4): 830, 1994.

11. Iuvone, P.M., Gan, J., Boatright, J.H., and Rubim, N.M. Modulation of dopaminergic neurotransmission in retina by melatonin: Presynaptic and postsynaptic mechanisms. Proc. Internat. Soc. Eye Res. 8: S.2, 1994.

12. Boatright, J.B., Borst, D.E., Nagpal, S., Ram, H., Si, J.S., and Nickerson, J.M. Characterization of trans-acting factors and cis-acting elements in the IRBP gene. Proc. Internat. Soc. Eye Res. 8: S.21, 1994.

13. Boatright, J.H., Borst, D.E., Lin, Z.-Y., Si, J.-S., Bhati, M. , Patel, D. , Bruno, J. and Nickerson, J.M. Functional characterization of cis-acting regulatory elements of the IRBP gene promoter region. Invest. Ophthalmol. Vis. Sci. 36(4): S123, 1995.

14. Bhati, M., Boatright, J.H., Borst, D.E., and Nickerson, J.M. Methylation mapping of the IRBP 5' flanking region. Invest. Ophthalmol. Vis. Sci. 37(3): S337, 1996.

15. Boatright, J.H., Si, J.-S., Patel, D., Peoples, J., and Nickerson, J.M. Functional characterization of a photoreceptor cis-acting element. Invest. Ophthalmol. Vis. Sci. 37(3): S337, 1996.

16. Boatright, J.H., Peoples, J.W., Edwards, C.L., Borst, D.E., Si, and Nickerson, J.M. The minimal regulated control region of the IRBP gene. Invest. Ophthalmol. Vis. Sci. 38(4): S241, 1997.

17. Peoples, J.W., Boatright, J.H., Si, S.-S., Edwards, C.L., Borst, D.E., Nickerson, J.M. Mutational analysis of the murine IRBP proximal promoter. Invest. Ophthalmol. Vis. Sci. 39(4): S46, 1998.

18. Farjo, Q., Mittal, B. Lee, C., Anderson, D. Peoples, J., Boatright, J., Nickerson, J.M., Chen, S., Zack, D., Swaroop, A. Regulation of a regulator: Studies on BZIP transcription factor NRL. Invest. Ophthalmol. Vis. Sci. 39(4): S197, 1998.

19. Saperstein, D.A., Chen, T., Boatright, J.H., Nickerson, J.M. PCR based qualitative and quantitative analysis of very low concentration unlabeled oligonucleotides. Invest. Ophthalmol. Vis. Sci. 39(4): S299, 1998.

20. Boatright, J.H., Peoples, J.W., Si, J.S., Edwards, C.L., Borst, D.E., Wang, Q.-L., Chen, S., Zack, D., Nickerson, J.M., Is CRX necessary and sufficient for IRBP expression? Invest. Ophthalmol. Vis. Sci. 39(4): S198, 1998.

21. Boatright, J.H., Peoples, J.W., Wang, Q.-L., Chen, S., Zack, D., Nickerson, J.M., IRBP Promoter Activity Requires Endogenous CRX. Invest. Ophthalmol. Vis. Sci. 40 (4): S939, 1999.

22. Boatright, J.H., Borst D.E., Wang, Q.-L., Chen, S., Zack, D., Nickerson, J.M.,Endogenous Crx expression and IRBP promoter activity in retinoblastoma cells. Invest. Ophthalmol. Vis. Sci. 41 (4): S388, 2000.

23. Saperstein, D.A., Chen, T., Boatright J.H. Characterization of the integrin alpha v beta 3 gene promoter in transiently transfected expressing and non-expressing cells. Invest. Ophthalmol. Vis. Sci. 41 (4): S636, 2000.

24. Nickerson, J.M., Li, G.R., Boatright, J.H., Rengarajan, K., Ruuska, S.E. Biochemical and biophysical properties of repeats of human IRBP. Invest. Ophthalmol. Vis. Sci. 41 (4): S331, 2000.

25. Boatright, J.H., Knox, B.E., Nguyen, H., Stodulkova, E., Borst, D.E., Nickerson, J.M. Evidence of a tissue restricting DNA regulatory element in the mouse IRBP promoter. Proc. Internat. Soc. Eye Res. 14: S195, 2000.

26. Nguyen, H.T., Knox, B.E., Stodulkova, E., Borst, D.E., Nickerson, J.M., Boatright, J.H. Characterizing tissue restricted IRBP gene expression. SURE Pgm Session 5: 44, 2000. <http://www.sciencenet.emory.edu/SURE/>.

27. Stodulkova E., Rengarajan K., Takasu I., Martin W.D., Padove S.A., Saperstein D.A., Nickerson J.M., Boatright J.H. Initial test of chimeraplasty in correcting a mouse retinal degeneration. Invest. Ophthalmol. Vis. Sci. 42 (4): S346, 2001.

28. Boatright, J.H., B.E. Knox, E. Stodulkova, H.T. Nguyen, S.A. Padove, E.A. Matheu, D.E. Borst, J.M. Nickerson. Tissue restricting dna regulatory elements in the mouse irbp promoter. Invest. Ophthalmol. Vis. Sci. 42 (4): S346, 2001.

29. Padove, S.A., H.T. Nguyen, J.M. Nickerson, K. Zhang, W. Baehr, J.H. Boatright. Initial isolation of irbp tissue restricting trans acting factors. Invest. Ophthalmol. Vis. Sci. 42 (4): S346, 2001.

30. Nickerson, J.M., C.S. Dodson, K. Rengarajan, H.D. Gewant, E. Stodulkova, H.T. Nguyen, J.H. Boatright. Extra hepatic expression of serum albumin mrna in mouse retina. Invest. Ophthalmol. Vis. Sci. 42 (4): S346, 2001.

31. Boatright JH, Stodulkova E, Nickerson JM. Endogenous gene repair of an animal model of retinitis pigmentosa. FASEB 2001 Summer Research Conference on the Biology and Chemistry of Vision. Jun. 2001.

32. Do, V.T., Padove, S.A., Nguyen, H.T., Stodulkova, E., Nickerson, J.M., Boatright, J.H. Characterization of a cis-acting element in the IRBP promoter. SURE Pgm Session 6: 44, 2001.

33. Lee SJ, Shuler RK, Sippy BD, Nickerson JM, Boatright JH, Grossniklaus HE. Murine Retinal/RPE/Choroidal Expression of ABCA1, ACAT1 and ACAT2. Invest. Ophthalmol. Vis. Sci. 43 (4): , 2002.

34. Sippy BD, Shuler RK, Lee SJ, Couse T, Wilcox JN, Boatright JH, Nickerson JM, Grossniklaus HE. ABCA1 Expression in Human RPE Cells and Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 43 (4): , 2002.

35. Boatright JH (moderator). Minisymposium: Oligonucleotide-mediated Gene Manipulation in the Eye. Invest. Ophthalmol. Vis. Sci. 43 (4): , 2002.

36. Rengarajan K, Stodulkova E, Do VT, Boatright JH, Nickerson JM. Identification of a mammalian IRBP tissue restricting transcription factor by EMSA and UV Photo-crosslinking and SDS-PAGE. Invest. Ophthalmol. Vis. Sci. 43 (4): , 2002.

37. Boatright JH, Stodulkova E, Nguyen HT, Do VT, Nickerson JM. The Effect of Retinoids and Butyrate on the Expression of CRX and IRBP in Retinoblastoma Cells. Invest. Ophthalmol. Vis. Sci. 43 (4): , 2002.

38. Padove SA, Do VT, Nguyen HT, Nickerson JM, Boatright JH. Characterization of DNA/protein complexes that restrict IRBP expression. Invest. Ophthalmol. Vis. Sci. 43 (4): , 2002.

39. Shuler RK, Boatright JH, Stodulkova E, Rengarajan K, Padove SA, Nickerson JM. Initial Investigation of Gene Repair in Ocular Tissues. Invest. Ophthalmol. Vis. Sci. 43 (4): , 2002.